Page 247 - 精细化工2019年第8期
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第 8 期                             陆婷婷,等: 3-氨基呋咱-4-羧酸的合成                                 ·1735·


            2.42,N:32.63,与 3-氨基呋咱-4-羧酸的理论元素                        molecule  inhibitors  for  the  β-catenin/T-cellfactor  protein-protein
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            值相似(C:27.92,H;2.34,N:32.55)。Meyer                      Journal of Medicinal Chemistry, 2015, 46: 113-128.
            的元素分析结果为 C:24.15,H;1.62,N:28.25,                   [4]   Sheremeteev A. Chemistry of furazan fused to five-membered rings[J].
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            与 3-氨基呋咱-4-羧酸的理论值相差较大。                             [5]   Churakov  A,  Semenov  S,  Ioffe  S,  et al.  The  oxidation  of  the
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            化合物进行重结晶,增加了成本;反应收率较低,
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            仅为 64%。                                            [11]  Zhai Lianjie (翟连杰), Wang Bozhou (王伯周), Li Yanan (李亚
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            基-2-肟基乙酸甲酯为原料的前提下,新方法的环化                           [18]  Eddy W, Brent D, Brian W, et al. Discovery of potent competitive
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